Site-Selective Artificial Ribonucleases: Renaissance of Oligonucleotide Conjugates for Irreversible Cleavage of RNA Sequences

RNA-targeting therapeutics require highly efficient sequence-specific devices capable of RNA irreversible degradation in vivo. The most developed methods of sequence-specific RNA cleavage, such as siRNA or antisense oligonucleotides (ASO), are currently based on recruitment of either intracellular m...

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Библиографические подробности

Главные авторы:	Yaroslav Staroseletz, Svetlana Gaponova, Olga Patutina, Elena Bichenkova, Bahareh Amirloo, Thomas Heyman, Daria Chiglintseva, Marina Zenkova
Формат:	Artigo
Язык:	Inglês
Опубликовано:	MDPI AG 2021-03-01
Серии:	Molecules
Предметы:	artificial ribonuclease oligonucleotide-peptide conjugate RNA cleavage neocuproine Tris(2-aminobenzimidazole) PNAzyme
Online-ссылка:	https://www.mdpi.com/1420-3049/26/6/1732
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