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Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...

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Asıl Yazarlar: Darya Novopashina, Mariya Vorobyeva, Anton Nazarov, Anna Davydova, Nikolay Danilin, Lyudmila Koroleva, Andrey Matveev, Alevtina Bardasheva, Nina Tikunova, Maxim Kupryushkin, Dmitrii Pyshnyi, Sidney Altman, Alya Venyaminova
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2019-07-01
Seri Bilgileri:Frontiers in Pharmacology
Konular:
bacterial RNase P
inhibition of RNase P
modified oligonucleotides
oligo(2’-O-methylribonucleotides)
phosphoryl guanidine oligonucleotides
peptide conjugates of oligonucleotides
Online Erişim:https://www.frontiersin.org/article/10.3389/fphar.2019.00813/full
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