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Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P

Novel alternatives to traditional antibiotics are now of great demand for the successful treatment of microbial infections. Here, we present the engineering and properties of new oligonucleotide inhibitors of RNase P, an essential bacterial enzyme. The series of 2’-O-methyl RNA (2’-OMe-RNA) and phos...

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Principais autores: Darya Novopashina, Mariya Vorobyeva, Anton Nazarov, Anna Davydova, Nikolay Danilin, Lyudmila Koroleva, Andrey Matveev, Alevtina Bardasheva, Nina Tikunova, Maxim Kupryushkin, Dmitrii Pyshnyi, Sidney Altman, Alya Venyaminova
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-07-01
Serier:Frontiers in Pharmacology
Fag:
bacterial RNase P
inhibition of RNase P
modified oligonucleotides
oligo(2’-O-methylribonucleotides)
phosphoryl guanidine oligonucleotides
peptide conjugates of oligonucleotides
Online adgang:https://www.frontiersin.org/article/10.3389/fphar.2019.00813/full
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