Impaired AIF-CHCHD4 interaction and mitochondrial calcium overload contribute to auditory neuropathy spectrum disorder in patient-iPSC-derived neurons with AIFM1 variant

Abstract Auditory neuropathy spectrum disorder (ANSD) is a hearing impairment caused by dysfunction of inner hair cells, ribbon synapses, spiral ganglion neurons and/or the auditory nerve itself. Approximately 1/7000 newborns have abnormal auditory nerve function, accounting for 10%-14% of cases of...

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Detalles Bibliográficos

Principais autores:	Yue Qiu, Hongyang Wang, Mingjie Fan, Huaye Pan, Jing Guan, Yangwei Jiang, Zexiao Jia, Kaiwen Wu, Hui Zhou, Qianqian Zhuang, Zhaoying Lei, Xue Ding, Huajian Cai, Yufei Dong, Lei Yan, Aifu Lin, Yong Fu, Dong Zhang, Qingfeng Yan, Qiuju Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2023-06-01
Series:	Cell Death and Disease
Acceso en liña:	https://doi.org/10.1038/s41419-023-05899-6
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