CiFi: accurate long-read chromosome conformation capture with low-input requirements

Abstract Hi-C characterizes three-dimensional chromatin organization, facilitates haplotype phasing, and enables genome-assembly scaffolding, but encounters difficulties across complex regions. By coupling chromosome conformation capture (3C) with PacBio HiFi long-read sequencing, here we develop a...

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Bibliografiske detaljer

Principais autores:	Sean P. McGinty, Gulhan Kaya, Sheina B. Sim, Alex Makunin, Renée L. Corpuz, Michael A. Quail, Mohamed Abuelanin, Mara K. N. Lawniczak, Scott M. Geib, Jonas Korlach, Megan Y. Dennis
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-12-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-66918-y
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