Homologous recombination occurs frequently at innate GT microsatellites in normal somatic and germ cells in vivo

Abstract Background In somatic cells, homologous recombination (HR) is a rare event caused by eventual DNA double-strand breaks (DSBs). In contrast, germ cells show high frequency of HR caused by programmed DSBs. Microsatellites are prone to DSBs during genome replication and, thereby, capable of pr...

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Dades bibliogràfiques

Autors principals:	Jianbo Zheng, Heng Li, Qi Zhang, Lei Sun, Xiangfang Liu, Chen Luo
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-05-01
Col·lecció:	BMC Genomics
Matèries:	Homologous recombination Genome replication GT microsatellites Somatic cells Germ cells
Accés en línia:	http://link.springer.com/article/10.1186/s12864-018-4758-y
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