Homologous recombination occurs frequently at innate GT microsatellites in normal somatic and germ cells in vivo

Abstract Background In somatic cells, homologous recombination (HR) is a rare event caused by eventual DNA double-strand breaks (DSBs). In contrast, germ cells show high frequency of HR caused by programmed DSBs. Microsatellites are prone to DSBs during genome replication and, thereby, capable of pr...

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Hlavní autoři:	Jianbo Zheng, Heng Li, Qi Zhang, Lei Sun, Xiangfang Liu, Chen Luo
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2018-05-01
Edice:	BMC Genomics
Témata:	Homologous recombination Genome replication GT microsatellites Somatic cells Germ cells
On-line přístup:	http://link.springer.com/article/10.1186/s12864-018-4758-y
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