Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors

The clinical successes of immune checkpoint blockade (ICB) in advanced cancer patients have recently spurred the clinical implementation of ICB in the neoadjuvant and perioperative setting. However, how neoadjuvant ICB therapy affects the systemic immune landscape and metastatic spread remains to be...

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Hlavní autoři:	Olga S. Blomberg, Kevin Kos, Lorenzo Spagnuolo, Olga I. Isaeva, Hannah Garner, Max D. Wellenstein, Noor Bakker, Danique E.M. Duits, Kelly Kersten, Sjoerd Klarenbeek, Cheei-Sing Hau, Daphne Kaldenbach, Elisabeth A.M. Raeven, Kim Vrijland, Marleen Kok, Karin E. de Visser
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2023-12-01
Edice:	OncoImmunology
Témata:	Breast cancer metastasis myeloid cells neoadjuvant immune checkpoint blockade regulatory T cells resistance mechanisms
On-line přístup:	https://www.tandfonline.com/doi/10.1080/2162402X.2023.2201147
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