Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort

Abstract Detecting homozygous deletion (HD) of CDKN2A is critical in BRAF-altered gliomas, as this molecular alteration has both diagnostic and prognostic significance. It is predominantly associated with BRAF-altered high-grade gliomas and has been associated with poorer prognosis in certain BRAF-a...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Thibaut Wolf, Damien Reita, Marlène Deschuyter, Chinar Salmanli, Julie Buffa, Erwan Pencreach, Eric Guérin, Eric Jeandidier, Marguerite Miguet, Marie-Pierre Chenard, Lucas Geyer, Georges Noel, Julien Todeschi, Guillaume Gauchotte, Sophie Martin, Natacha Entz-Werlé, Benoît Lhermitte
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
Colecção:	Acta Neuropathologica Communications
Assuntos:	p16 CDKN2A homozygous deletion FISH DNA methylation BRAF-altered gliomas
Acesso em linha:	https://doi.org/10.1186/s40478-025-02089-7
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!