Challenging CDKN2A assessment in BRAF-altered gliomas: lessons from a pleomorphic xanthoastrocytoma-enriched cohort

Abstract Detecting homozygous deletion (HD) of CDKN2A is critical in BRAF-altered gliomas, as this molecular alteration has both diagnostic and prognostic significance. It is predominantly associated with BRAF-altered high-grade gliomas and has been associated with poorer prognosis in certain BRAF-a...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Thibaut Wolf, Damien Reita, Marlène Deschuyter, Chinar Salmanli, Julie Buffa, Erwan Pencreach, Eric Guérin, Eric Jeandidier, Marguerite Miguet, Marie-Pierre Chenard, Lucas Geyer, Georges Noel, Julien Todeschi, Guillaume Gauchotte, Sophie Martin, Natacha Entz-Werlé, Benoît Lhermitte
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2025-08-01
Σειρά:	Acta Neuropathologica Communications
Θέματα:	p16 CDKN2A homozygous deletion FISH DNA methylation BRAF-altered gliomas
Διαθέσιμο Online:	https://doi.org/10.1186/s40478-025-02089-7
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!