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Inherent limitations of probabilistic models for protein-DNA binding specificity.

The specificities of transcription factors are most commonly represented with probabilistic models. These models provide a probability for each base occurring at each position within the binding site and the positions are assumed to contribute independently. The model is simple and intuitive and is...

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Detalles Bibliográficos
Autores principales: Shuxiang Ruan, Gary D Stormo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2017-07-01
Colección:PLoS Computational Biology
Acceso en línea:http://europepmc.org/articles/PMC5521849?pdf=render
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