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Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2017-06-01
Rangatū:Scientific Reports
Urunga tuihono:https://doi.org/10.1038/s41598-017-04461-7
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