Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

Abstract Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that allows swift modification of the...

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Principais autores:	Joren Guillaume, Jing Wang, Jonas Janssens, Soumya G. Remesh, Martijn D. P. Risseeuw, Tine Decruy, Mathy Froeyen, Dirk Elewaut, Dirk M. Zajonc, Serge Van Calenbergh
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2017-06-01
Series:	Scientific Reports
Acceso en liña:	https://doi.org/10.1038/s41598-017-04461-7
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