Deep exploration of the TCR CDR3β repertoire specific for viral CD4 T-cell epitopes inside the circulating T-cell repertoire

IntroductionThis study provides an in-depth analysis of the diversity of the CD4 TCR CDR3β repertoire specific to influenza A (HA) and Epstein-Barr virus (EBNA) epitopes.MethodsEpitope-specific CD4 T cells from 13 healthy donors were enriched using a short-term culture step, isolated based on activa...

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Hlavní autoři:	Gautier Lhomme, Rémi Giraudet, Valéria Porcheddu, Evelyne Correia, Robert Olaso, Stephane Hua, Bernard Maillere
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-11-01
Edice:	Frontiers in Immunology
Témata:	TCR clonotypes repertoire viral epitopes HLA class II
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1713225/full
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