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Regulation of heterologous subtilin production in Bacillus subtilis W168

Abstract Background Subtilin is a peptide antibiotic (lantibiotic) natively produced by Bacillus subtilis ATCC6633. It is encoded in a gene cluster spaBTCSIFEGRK (spa-locus) consisting of four transcriptional units: spaS (subtilin pre-peptide), spaBTC (modification and export), spaIFEG (immunity) an...

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Kaydedildi:
Asıl Yazarlar: Qian Zhang, Carolin M. Kobras, Susanne Gebhard, Thorsten Mascher, Diana Wolf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMC 2022-04-01
Seri Bilgileri:Microbial Cell Factories
Konular:
Lantibiotic subtilin
Heterologous expression
Bacillus subtilis W168
spa-locus
Biosynthesis regulation
Two-component system (TCS)
Online Erişim:https://doi.org/10.1186/s12934-022-01782-9
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