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Stepping forward: T-cell redirecting bispecific antibodies in cancer therapy

T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens, thereby engaging with CD3 on the T cell receptor. This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells. Th...

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Principais autores: Xiaojing Qin, Wenjing Ning, Han Liu, Xue Liu, Wenxin Luo, Ningshao Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-06-01
coleção:Acta Pharmaceutica Sinica B
Assuntos:
Bispecific antibody (BsAbs)
T-cell redirecting BsAbs
Tumor-associated antigens
Toxicity
Cytokine release syndrome
Tumor microenvironment
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211383524001084
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