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Stepping forward: T-cell redirecting bispecific antibodies in cancer therapy

T cell-redirecting bispecific antibodies are specifically designed to bind to tumor-associated antigens, thereby engaging with CD3 on the T cell receptor. This linkage between tumor cells and T cells actively triggers T cell activation and initiates targeted killing of the identified tumor cells. Th...

Deskribapen osoa

Gorde:
Egile Nagusiak: Xiaojing Qin, Wenjing Ning, Han Liu, Xue Liu, Wenxin Luo, Ningshao Xia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2024-06-01
Saila:Acta Pharmaceutica Sinica B
Gaiak:
Bispecific antibody (BsAbs)
T-cell redirecting BsAbs
Tumor-associated antigens
Toxicity
Cytokine release syndrome
Tumor microenvironment
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S2211383524001084
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