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Dihydropyridine Calcium Channel Blockers Suppress the Transcription of PD-L1 by Inhibiting the Activation of STAT1

Programmed death ligand 1 (PD-L1) which is upregulated in various epithelial tumors, plays a central role in the evasion of the immune system. In addition to monoclonal antibodies that blocking PD1/PD-L1 axis, finding small molecule compounds that can suppress PD-L1 expression might be another subst...

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Principais autores: Xiaohui Pan, Run Li, Hongjie Guo, Wenxin Zhang, Xiaqing Xu, Xi Chen, Ling Ding
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
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Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2020.539261/full
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