The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress
Fluid shear stress mechanotransduction by Notch1: flow stimulates Notch1 intracellular domain interactions to polarize receptors into microdomains, driving endocytosis and proteolytic activation. Hemodynamic shear stress regulates endothelial phenotype through activation of Notch1 signaling, yet the...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Life Science Alliance LLC
2026-04-01
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| Serier: | Life Science Alliance |
| Online adgang: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202503599 |
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