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The Notch1 intracellular domain orchestrates mechanotransduction of fluid shear stress

Fluid shear stress mechanotransduction by Notch1: flow stimulates Notch1 intracellular domain interactions to polarize receptors into microdomains, driving endocytosis and proteolytic activation. Hemodynamic shear stress regulates endothelial phenotype through activation of Notch1 signaling, yet the...

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Bibliografiset tiedot
Päätekijät: Tania Singh, Kyle A Jacobs, William J Polacheck, Matthew L Kutys
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Life Science Alliance LLC 2026-04-01
Sarja:Life Science Alliance
Linkit:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202503599
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