Simplified and Rapid Determination of Primaquine and 5,6-Orthoquinone Primaquine by UHPLC-MS/MS: Its Application to a Pharmacokinetic Study

The method for the determination of primaquine (PQ) and 5,6-orthoquinone primaquine (5,6-PQ), the representative marker for PQ active metabolites, via CYP2D6 in human plasma and urine has been validated. All samples were extracted using acetonitrile for protein precipitation and analyzed using the u...

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Detalhes bibliográficos

Principais autores:	Waritda Pookmanee, Siriwan Thongthip, Jeeranut Tankanitlert, Mathirut Mungthin, Chonlaphat Sukasem, Supeecha Wittayalertpanya
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-07-01
Colecção:	Molecules
Assuntos:	primaquine 5,6-orthoquinone-primaquine plasma urine
Acesso em linha:	https://www.mdpi.com/1420-3049/26/14/4357
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