Mitochondrial contact site and cristae organizing system (MICOS) machinery supports heme biosynthesis by enabling optimal performance of ferrochelatase

Heme is an essential cofactor required for a plethora of cellular processes in eukaryotes. In metazoans the heme biosynthetic pathway is typically partitioned between the cytosol and mitochondria, with the first and final steps taking place in the mitochondrion. The pathway has been extensively stud...

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Autori principali:	Jonathan V. Dietz, Mathilda M. Willoughby, Robert B. Piel, III, Teresa A. Ross, Iryna Bohovych, Hannah G. Addis, Jennifer L. Fox, William N. Lanzilotta, Harry A. Dailey, James A. Wohlschlegel, Amit R. Reddi, Amy E. Medlock, Oleh Khalimonchuk
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2021-10-01
Serie:	Redox Biology
Soggetti:	Mitochondria Heme MICOS Ferrochelatase Yeast
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2213231721002846
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