Detecting Genetic Mosaicism in Cultures of Human Pluripotent Stem Cells

Genetic changes in human pluripotent stem cells (hPSCs) gained during culture can confound experimental results and potentially jeopardize the outcome of clinical therapies. Particularly common changes in hPSCs are trisomies of chromosomes 1, 12, 17, and 20. Thus, hPSCs should be regularly screened...

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Bibliografiske detaljer

Principais autores:	Duncan Baker, Adam J. Hirst, Paul J. Gokhale, Miguel A. Juarez, Steve Williams, Mark Wheeler, Kerry Bean, Thomas F. Allison, Harry D. Moore, Peter W. Andrews, Ivana Barbaric
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2016-11-01
Serier:	Stem Cell Reports
Fag:	Human pluripotent stem cells genetic changes detection methods sensitivity
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2213671116302417
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