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Potential mechanisms of resistance to venetoclax and strategies to circumvent it

Abstract Background Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy. It is also being evaluated in numerous clinical trials for tre...

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Váldodahkkit: Stephen K. Tahir, Morey L. Smith, Paul Hessler, Lisa Roberts Rapp, Kenneth B. Idler, Chang H. Park, Joel D. Leverson, Lloyd T. Lam
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2017-06-01
Ráidu:BMC Cancer
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Liŋkkat:http://link.springer.com/article/10.1186/s12885-017-3383-5
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