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Coxiella burnetii effector CvpE maintains biogenesis of Coxiella-containing vacuoles by suppressing lysosome tubulation through binding PI(3)P and perturbing PIKfyve activity on lysosomes

Coxiella burnetii (C. burnetii) is the causative agent of Q fever, a zoonotic disease. Intracellular replication of C. burnetii requires the maturation of a phagolysosome-like compartment known as the replication permissive Coxiella-containing vacuole (CCV). Effector proteins secreted by the Dot/Icm...

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Main Authors: Mingliang Zhao, Shan Zhang, Weiqiang Wan, Chunyu Zhou, Nana Li, Ruxi Cheng, Yonghui Yu, Xuan Ouyang, Dongsheng Zhou, Jun Jiao, Xiaolu Xiong
Format: Artigo
Language:Inglês
Published: Taylor & Francis Group 2024-12-01
Series:Virulence
Subjects:
Coxiella burnetii
effector proteins
Coxiella-containing vacuoles
lysosomes
Coxiella vacuolar protein E
Online Access:https://www.tandfonline.com/doi/10.1080/21505594.2024.2350893
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