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Dysregulated mitochondrial homeostasis and DNA repair in the progression from colon adenoma to cancer

Abstract Background While nuclear DNA (nDNA) damage and alterations in nDNA repair are known to play a role in colon cancer (CC), there is insufficient research investigating these processes in mitochondrial DNA (mtDNA). Methods This study investigates mtDNA changes in CC, focusing on mitochondrial...

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Hoofdauteurs: Natalie Danesova, Josef Horak, Anna Valickova, Adrian Gil-Korilis, Jorge Ergui-Arbizu, Richard Palek, Jan Bruha, Miroslav Levy, Pavel Skrobanek, Jan Kral, Jiri Jungwirth, Jiri Neuzil, Veronika Vymetalkova, Pavel Vodicka, Sona Vodenkova, Kristyna Tomasova
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2025-11-01
Reeks:Molecular Medicine
Onderwerpen:
Colorectal cancer
Colon adenomas
Biomarkers
Mitochondria
Mitochondrial DNA damage
Mitochondrial DNA repair
Online toegang:https://doi.org/10.1186/s10020-025-01400-5
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