Evaluation of the Role of AID-Induced Mutagenesis in Resistance to B-Cell Receptor Pathway Inhibitors in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) is the most common leukemia in Western countries, and B-cell receptor (BCR) pathway inhibitors such as idelalisib and ibrutinib are currently established therapies for CLL. Although effective, these drugs frequently lead to resistance, but the mechanisms are still...

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Detalhes bibliográficos

Principais autores:	Chiara Pighi, Alessandro Gasparetto, Elisa Genuardi, Jianli Tao, Qi Wang, Candida Vitale, Valentina Griggio, Rocco Piazza, Sabino Ciavarella, Marta Coscia, Simone Ferrero, Alberto Zamò, Claudia Voena, Roberto Chiarle
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-12-01
coleção:	Current Issues in Molecular Biology
Assuntos:	Chronic Lymphocytic Leukemia (CLL) activation-induced cytidine deaminase (AID) idelalisib ibrutinib drug resistance
Acesso em linha:	https://www.mdpi.com/1467-3045/47/12/1031
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