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Biochemical characterization of DNA damage checkpoint complexes: clamp loader and clamp complexes with specificity for 5' recessed DNA.

The cellular pathways involved in maintaining genome stability halt cell cycle progression in the presence of DNA damage or incomplete replication. Proteins required for this pathway include Rad17, Rad9, Hus1, Rad1, and Rfc-2, Rfc-3, Rfc-4, and Rfc-5. The heteropentamer replication factor C (RFC) lo...

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Autori principali: Viola Ellison, Bruce Stillman
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2003-11-01
Serie:PLoS Biology
Accesso online:http://europepmc.org/articles/PMC261875?pdf=render
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