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Blocking the WNT/β-catenin pathway in cancer treatment:pharmacological targets and drug therapeutic potential

The WNT/β-catenin signaling pathway plays crucial roles in tumorigenesis and relapse, metastasis, drug resistance, and tumor stemness maintenance. In most tumors, the WNT/β-catenin signaling pathway is often aberrantly activated. The therapeutic usefulness of inhibition of WNT/β-catenin signaling ha...

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Wedi'i Gadw mewn:
Prif Awduron: Xi Zhao, Yunong Ma, Jiayang Luo, Kexin Xu, Peilin Tian, Cuixia Lu, Jiaxing Song
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2024-08-01
Cyfres:Heliyon
Pynciau:
WNT/β-catenin
Drug target
Drug discovery
Medicinal research
Drug development
Mynediad Ar-lein:http://www.sciencedirect.com/science/article/pii/S2405844024120208
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