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MEDAG expression in vitro and paeoniflorin alleviates bone loss by regulating the MEDAG/AMPK/PPARγ signaling pathway in vivo

Objectives: Osteoporosis (OP) is characterized by reduced bone mass and impaired bone microstructure. Paeoniflorin (PF) is isolated from peony root with anti-inflammatory, immunomodulatory, and bone-protective effects. Up to now, the mechanism of anti-OP in PF has not been completely clarified. Meth...

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Auteurs principaux: Haixia Liu, Zhiyue Chang, Shuling Liu, Ruyuan Zhu, Jiayi Ma, Xinyue Lu, Lei Li, Zhiguo Zhang
Format: Artigo
Langue:Inglês
Publié: Elsevier 2024-01-01
Collection:Heliyon
Sujets:
Osteoporosis
Paeoniflorin
Ovariectomized
MEDAG/AMPK/PPARγ signaling pathway
Lipid metabolism
Accès en ligne:http://www.sciencedirect.com/science/article/pii/S240584402400272X
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