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A novel humanized immune stroma PDX cancer model for therapeutic studies

Abstract Standard preclinical human tumor models lack a human tumor stroma. However, as stroma contributes to therapeutic resistance, the lack of human stroma may make current models less stringent for testing new therapies. To address this, using patient-derived tumor cells, patient-derived cancer-...

Cur síos iomlán

Sábháilte in:
Príomhchruthaitheoirí: Dongli Yang, Ian Beddows, Huijuan Tang, Shoumei Bai, Sandra Cascio, Stacy C. McGonigal, Benjamin K. Johnson, John J. Powers, Rajesh Acharya, Riyue Bao, Tullia C. Bruno, T. Rinda Soong, Jose R. Conejo-Garcia, Hui Shen, Moses T. Bility, Ronald J. Buckanovich
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Springer 2026-03-01
Sraith:Cancer Immunology, Immunotherapy
Ábhair:
Humanized stroma tumor model
Immunotherapy
Targeted therapy
Ovarian cancer
Tumor-associated macrophage
Hedgehog
Rochtain ar líne:https://doi.org/10.1007/s00262-026-04349-4
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