Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

ABSTRACT Heligmosomoides polygyrus, a mouse parasite, modulates host immunity by secreting modular transforming growth factor‐β (TGFβ) mimics (TGMs). The agonist TGM1 interacts with TGFBR1, TGFBR2, and the co‐receptor CD44 through domains D1/2, D3, and D4/5, respectively. In contrast, the antagonist...

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Bibliografiska uppgifter

Huvudupphov:	Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter vanVeelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Wiley 2026-07-01
Serie:	Advanced Science
Ämnen:	betaglycan bispecific antibodies heligmosomoides polygyrus lipoprotein receptor‐related protein molecular mimicry signal transduction
Länkar:	https://doi.org/10.1002/advs.75322
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