The TGF-β mimic TGM4 achieves cell specificity through combinatorial surface co-receptor binding

Abstract The immunoregulatory cytokine TGF-β is pleiotropic due to the near-ubiquitous expression of the TGF-β receptors TβRI and TβRII on diverse cell types. The helminth parasite Heligmosomoides polygyrus has convergently evolved a family of TGF-β mimics (TGMs) that bind both these receptors throu...

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Autori principali:	Shashi P Singh, Danielle J Smyth, Kyle T Cunningham, Ananya Mukundan, Chang-Hyeock Byeon, Cynthia S Hinck, Madeleine P J White, Claire Ciancia, Natalia Wąsowska, Anna Sanders, Regina Jin, Ruby F White, Sergio Lilla, Sara Zanivan, Christina Schoenherr, Gareth J Inman, Maarten van Dinther, Peter ten Dijke, Andrew P Hinck, Rick M Maizels
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2024-11-01
Serie:	EMBO Reports
Soggetti:	Agonist Antagonist Cytokine Helminth Receptor
Accesso online:	https://doi.org/10.1038/s44319-024-00323-2
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