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Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium.

<h4>Background</h4>Gene therapy mediated by synthetic vectors may provide opportunities for new treatments for cystic fibrosis (CF) via aerosolisation. Vectors for CF must transfect the airway epithelium efficiently and not cause inflammation so they are suitable for repeated dosing. The inhaled aer...

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Autori principali: Maria D I Manunta, Robin J McAnulty, Aristides D Tagalakis, Stephen E Bottoms, Frederick Campbell, Helen C Hailes, Alethea B Tabor, Geoffrey J Laurent, Christopher O'Callaghan, Stephen L Hart
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2011-01-01
Serie:PLoS ONE
Accesso online:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0026768&type=printable
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