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COBRA methods and metabolic drug targets in cancer

The identification of therapeutic strategies exploiting the metabolic alterations of malignant cells is a relevant area in cancer research. Here, we discuss a novel computational method, based on the COBRA (COnstraint-Based Reconstruction and Analysis) framework for metabolic networks, to perform th...

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Автори: Iñigo Apaolaza, Edurne San José-Eneriz, Xabier Agirre, Felipe Prósper, Francisco J. Planes
Формат: Artigo
Мова:Inglês
Опубліковано: Taylor & Francis Group 2018-01-01
Серія:Molecular & Cellular Oncology
Предмети:
cancer
constraint-based reconstruction and analysis
drug targets
essential genes
genetic minimal cut sets
metabolic networks
personalized medicine
synthetic lethality
Онлайн доступ:http://dx.doi.org/10.1080/23723556.2017.1389672
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