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Dual epigenetic modifiers for cancer therapy

Epigenetic drug discovery is an emerging strategy for the treatment of cancer and other pathologies. Here, we discuss our recent discovery of first-in-class dual reversible inhibitors of the histone methyltransferase activity of G9a/EHMT2 and DNA methyltransferases showing in vivo efficacy in human...

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Autori principali: Edurne San José-Enériz, Obdulia Rabal, Xabier Agirre, Julen Oyarzabal, Felipe Prosper
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis Group 2017-07-01
Serie:Molecular & Cellular Oncology
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Accesso online:http://dx.doi.org/10.1080/23723556.2017.1342748
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