Synthetic lethal interactions of DEAD/H-box helicases as targets for cancer therapy

DEAD/H-box helicases are implicated in virtually every aspect of RNA metabolism, including transcription, pre-mRNA splicing, ribosomes biogenesis, nuclear export, translation initiation, RNA degradation, and mRNA editing. Most of these helicases are upregulated in various cancers and mutations in so...

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Autors principals:	Ananna Bhadra Arna, Hardikkumar Patel, Ravi Shankar Singh, Frederick S. Vizeacoumar, Anthony Kusalik, Andrew Freywald, Franco J. Vizeacoumar, Yuliang Wu
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-01-01
Col·lecció:	Frontiers in Oncology
Matèries:	DEAD/H-box helicase synthetic lethality synthetic dosage lethality therapeutic target drug development cancer
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fonc.2022.1087989/full
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