Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models

Abstract Alpha‑synuclein (α‑syn) overexpression models are widely used to unravel the molecular mechanisms of Parkinson’s disease (PD), particularly in light of the dose-dependent transition between its physiological and toxic roles. However, existing systems rely on inducible expression, lack robus...

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Autori principali:	Miraj Ud Din Momand, Petra Majerova, Diana Mjartinova, Natalia Maruskinova, Karolina Albertusova, Michael Dobrota, Lubica Fialova, Sara Stefankova, Petar Podlesniy, Muhammad Khalid Muhammadi, Miroslav Balaz, Dominika Fricova
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2026-02-01
Serie:	Cellular and Molecular Life Sciences
Soggetti:	Alpha-synuclein SH-SY5Y ReNcell VM Cell models Parkinson’s disease
Accesso online:	https://doi.org/10.1007/s00018-026-06126-z
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