Alpha-synuclein overexpression triggers divergent cellular responses and post-translational modifications in SH-SY5Y and ReNcell VM models

Abstract Alpha‑synuclein (α‑syn) overexpression models are widely used to unravel the molecular mechanisms of Parkinson’s disease (PD), particularly in light of the dose-dependent transition between its physiological and toxic roles. However, existing systems rely on inducible expression, lack robus...

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Autores principales:	Miraj Ud Din Momand, Petra Majerova, Diana Mjartinova, Natalia Maruskinova, Karolina Albertusova, Michael Dobrota, Lubica Fialova, Sara Stefankova, Petar Podlesniy, Muhammad Khalid Muhammadi, Miroslav Balaz, Dominika Fricova
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer 2026-02-01
Colección:	Cellular and Molecular Life Sciences
Materias:	Alpha-synuclein SH-SY5Y ReNcell VM Cell models Parkinson’s disease
Acceso en línea:	https://doi.org/10.1007/s00018-026-06126-z
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