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Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease that is characterized by vascular remodeling of the pulmonary artery. PAH remodeling is primarily caused by the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs). Therefore, an inhibitory mechanism is e...

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Hlavní autoři: Akiko Kawade, Aya Yamamura, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2023-02-01
Edice:Journal of Pharmacological Sciences
Témata:
Pulmonary hypertension
Corosolic acid
Pulmonary artery
Smooth muscle
Signal transducer and activator of transcription 3
On-line přístup:http://www.sciencedirect.com/science/article/pii/S1347861322000950
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