A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction
To mitigate risks in central nervous system (CNS) drug development, we established a high-throughput in vitro blood-brain barrier (BBB) model using LLC-PK1-MOCK and LLC-PK1-MDR1 cells in a Transwell system, aiming to replicate in vivo brain distribution and elucidate permeability mechanisms. Model i...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis Group
2025-12-01
|
| Colección: | Drug Delivery |
| Materias: | |
| Acceso en línea: | https://www.tandfonline.com/doi/10.1080/10717544.2025.2585612 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|