A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction

To mitigate risks in central nervous system (CNS) drug development, we established a high-throughput in vitro blood-brain barrier (BBB) model using LLC-PK1-MOCK and LLC-PK1-MDR1 cells in a Transwell system, aiming to replicate in vivo brain distribution and elucidate permeability mechanisms. Model i...

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Bibliografische Detailangaben

Hauptverfasser:	Juanwen Hu, Xue Jiang, Cong Li, Qiannan Zhang, Xia Wu, Wenpeng Zhang, Xiaomei Zhuang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2025-12-01
Schriftenreihe:	Drug Delivery
Schlagworte:	LLC-PK1-MDR1 cells blood-brain barrier CNS drug surrogate barrier model
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/10717544.2025.2585612
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