Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS). As such, GCs inhibit the activity of downstream effector cytokines, such as tumor necrosis factor (TNF). PPARα (NR1C1) is a nuclear recep...

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Detalhes bibliográficos

Principais autores:	Nadia Bougarne, Viacheslav Mylka, Dariusz Ratman, Ilse M. Beck, Jonathan Thommis, Lode De Cauwer, Jan Tavernier, Bart Staels, Claude Libert, Karolien De Bosscher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-08-01
coleção:	Frontiers in Immunology
Assuntos:	PPARα GRα crosstalk molecular mechanism inflammation MSK1
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.01769/full
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