ERRα suppression enhances the cytotoxicity of the MEK inhibitor trametinib against colon cancer cells

Abstract Background ERRα, a constitutive transcription factor that regulates energy metabolism, plays an important role in the progression of various tumours. However, its role in cell survival and proliferation and its implication in targeted therapy in colon cancer remains elusive. Methods The exp...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Sheng Zhou, Hongwei Xia, Huanji Xu, Qiulin Tang, Yongzhan Nie, Qi yong Gong, Feng Bi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-09-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Oestrogen-related receptor α (ERRα) Epidermal growth factor (EGF) Trametinib Simvastatin
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-018-0862-8
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!