LRRK2 negatively regulates glucose tolerance via regulation of membrane translocation of GLUT4 in adipocytes

Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine‐rich repeat kinase 2 (LRRK2)‐associated Parkinson's disease (PD). However, the physiological significance of this association is unclear. In the present study, we investigated the effect of LRRK2 on h...

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Detalhes bibliográficos

Principais autores:	Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2023-12-01
coleção:	FEBS Open Bio
Assuntos:	adipocyte glucose tolerance GLUT4 LRRK2 Rab GTPase
Acesso em linha:	https://doi.org/10.1002/2211-5463.13717
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