Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma
Abstract The von Hippel-Lindau (VHL) tumor suppressor is a substrate-defining component of E3 ubiquitin ligase complexes that target cellular substrates for proteasome-mediated degradation. VHL inactivation by mutation or transcriptional silencing is observed in most sporadic cases of clear cell ren...
Wedi'i Gadw mewn:
| Prif Awduron: | , , , , , , , , , , , |
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| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Nature Publishing Group
2025-04-01
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| Cyfres: | Cell Death and Disease |
| Mynediad Ar-lein: | https://doi.org/10.1038/s41419-025-07623-y |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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