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PPARγ activation by leriglitazone counteracts neurodegeneration and neuroinflammation in a disease-relevant mouse model of COASY dysfunction

Coenzyme A (CoA) is a vital cofactor involved in energy metabolism, lipid biosynthesis, protein modification, and epigenetic regulation. Disruptions in CoA biosynthesis have been implicated in neurometabolic disorders such as pantothenate kinase-associated neurodegeneration (PKAN) and COASY protein-...

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Principais autores: Chiara Cavestro, Floriana Cascone, Andrea Legati, Rossella Izzo, Marcella Catania, Cristina Vergara, Laura Rodríguez-Pascau, Pilar Pizcueta, Valeria Tiranti, Ivano Di Meo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:Pharmacological Research
Fag:
Coenzyme A
CoPAN
NBIA
Neuroinflammation
Animal models
PPARγ
Online adgang:http://www.sciencedirect.com/science/article/pii/S1043661826001088
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