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PPARγ activation by leriglitazone counteracts neurodegeneration and neuroinflammation in a disease-relevant mouse model of COASY dysfunction

Coenzyme A (CoA) is a vital cofactor involved in energy metabolism, lipid biosynthesis, protein modification, and epigenetic regulation. Disruptions in CoA biosynthesis have been implicated in neurometabolic disorders such as pantothenate kinase-associated neurodegeneration (PKAN) and COASY protein-...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Chiara Cavestro, Floriana Cascone, Andrea Legati, Rossella Izzo, Marcella Catania, Cristina Vergara, Laura Rodríguez-Pascau, Pilar Pizcueta, Valeria Tiranti, Ivano Di Meo
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2026-05-01
Rangatū:Pharmacological Research
Ngā marau:
Coenzyme A
CoPAN
NBIA
Neuroinflammation
Animal models
PPARγ
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S1043661826001088
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