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Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma

Abstract We previously reported a novel association between CDKN2A nonpromoter methylation and transcription (ARF/INK4a) in human papillomavirus associated oropharyngeal tumors. In this study we assessed whether nonpromoter CDKN2A methylation in laryngeal squamous cell carcinomas (LXSCC) conferred a...

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Asıl Yazarlar: Miriam M. Ben‐Dayan, Thomas J. Ow, Thomas J. Belbin, Joshua Wetzler, Richard V. Smith, Geoffrey Childs, Brenda Diergaarde, D. Neil Hayes, Jennifer R. Grandis, Michael B. Prystowsky, Nicolas F. Schlecht
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2017-02-01
Seri Bilgileri:Cancer Medicine
Konular:
CDKN2A
gene transcription
larynx cancer
methylation
p14(ARF)
p16(INK4a)
Online Erişim:https://doi.org/10.1002/cam4.961
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