Enhanced Activity and Substrate Specificity by Site‐Directed Mutagenesis for the P450 119 Peroxygenase Catalyzed Sulfoxidation of Thioanisole

Abstract P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert‐butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min−1 and 196 min−1 respectively. Several mutants were designed to improve the pero...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Xiaoyao Wei, Dr. Chun Zhang, Dr. Xiaowei Gao, Yanping Gao, Ya Yang, Dr. Kai Guo, Xi Du, Lin Pu, Prof. Dr. Qin Wang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Wiley-VCH 2019-08-01
Rangatū:	ChemistryOpen
Ngā marau:	P450 peroxygenase site-directed mutagenesis sulfoxidation reactions turnover rate catalytic mechanism
Urunga tuihono:	https://doi.org/10.1002/open.201900157
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!